The Indo-Czech duo lost 3-6, 6-0, 10-7 to top seeds Mike and Bob Bryan in the Cincinnati Masters semi-final.
The world number one battled back from a break down in the final set to fend off the Aussie and reach the final of the Cincinnati Masters.
Hewitt was in commanding form as he beat Carlos Moya 6-2, 6-4 to reach the semi-finals of the Cincinnati Masters, setting up a clash with top seed Roger Federer.
Sania Mirza was the only Indian left competing in the Western and Southern Open by reaching the semi-finals as Leander Paes and Rohan Bopanna were ousted from the men's doubles with their respective partners in Cincinnati.
Novak Djokovic, Andy Murray, Rafael Nadal and Roger Federer all picked up third round wins at the Western and Southern Open on Thursday to set up a star-studded last eight in Cincinnati.
Rohan Bopanna and Florin Mergea saved a match-point before emerging winners, while Sania Mirza and Martin Hingis were also tested en route to the quarter-finals of the ATP/WTA Western and Southern Open, in Cincinnati, on Thursday.
World number three Andy Murray has withdrawn from next week's inaugural $5.25 million Shanghai Masters because of a wrist injury, organisers said on Thursday.
Rohan Bopanna revealed that he will bring curtains down on his Davis Cup career when the country hosts Morocco in September
Nadal produced a rich vein of form as he thrashed Greek teenager Stefanos Tsitsipas in straight sets to clinch his fourth Canadian Masters 1000 title at the Rogers Cup
Novak Djokovic has sealed the year-end men's world number one tennis ranking for the sixth time to go level with childhood hero Pete Sampras after closest rival Rafael Nadal opted against playing in the ATP Tour event in Sofia next week.
Mahesh Bhupathi and Rohan Bopanna clinched the Paris Masters, their second title of the year, after scoring a hard-fought win over Aisam-ul-haq Qureshi and Jean-Julien Rojer, on Sunday.
India's campaign came to an end at the Western and Southern Open after Sania Mirza and her Swiss partner Martina Hingis crashed out.
Nadal's great rival and fellow 20-times Grand Slam winner Roger Federer is also out of the US Open and will be sidelined for many months because he needs knee surgery.
Djokovic etched his name in history by clinching a record 24 Grand Slam titles
An elbow injury forced Djokovic to retire against Czech Tomas Berdych in the quarter-finals of Wimbledon in 2017. After that came a series of early tournament exits and, finally, surgery.
American twins Bob and Mike Bryan added another accolade to their lengthy resume after taking the Shanghai Masters men's doubles title on Sunday to become the first pair to win all nine ATP World Tour Masters 1000 tournaments.
Asked about the challenges of an interfaith marriage, she said, 'There are a lot of things that we just agree on, I think, especially when it comes to family life, how to raise our kids. And so I think the answer really is, we just talk a lot.'
Serena Williams brushed off some serving troubles before cruising to a 6-4, 6-3 win over Elina Svitolina on Saturday and will meet Simona Halep in the Western & Southern Open final.
A summary of sports events and sports persons, who made news on Monday.
A summary of Friday's tennis action from around the world.
Victoria Azarenka displayed the kind of form that could lead her to a hat-trick of Australian Open titles later this month by brushing aside German fourth seed Angelique Kerber 6-3, 6-1 in the Brisbane International final on Saturday.
The Scot lost 6-4, 6-4 to Richard Gasquet in his first singles match since January before saying he had turned down a wild card into the men's draw at the year's final Grand Slam.
'I don't want to rush anything or put a timeline on my recovery. I'm going to listen to my body and step back on the court to compete when the time is right'
It was Roger Federer's fastest defeat since losing to Franco Squillari in 54 minutes in Sydney in 2003.
It will be the 22nd career match-up between the two long-time rivals, who somehow have avoided each other at the US Open throughout their long careers.
While prone to losing to modest opponents, Kyrgios often produces his best tennis when up against one of the 'Big Three' of Novak Djokovic, Roger Federer and Nadal.
World No 2 Djokovic, who received a first-round bye, broke his opponent's serve four times to extend his winning run to 19 matches.
Former world number one Serena Williams looked sharp in her return to the hardcourts after a week-long break, soundly defeating Daria Gavrilova 6-1, 6-2 on Monday to advance to the second round of the Cincinnati Masters.
Roger Federer avenged his Wimbledon final loss to Novak Djokovic by beating the top-seeded Serb 7-6(1), 6-3 on Sunday to capture his second consecutive Western & Southern Open title.
India's tennis star Sania Mirza retained her numero uno status in women's doubles for the second consecutive year, despite failing to defend the WTA Finals Singapore title with partner Martina Hingis. Defending champions Sania and Hingis had lost to Ekaterina Makarova and Elena Vesnina in the semi-finals of the WTA Finals Singapore on Saturday.
World number one Naomi Osaka will "probably" defend her US Open title, even if it means defying her doctor's orders.
Karolina Pliskova overcame a slow start before beating Garbie Muguruza 4-6, 6-2, 7-6 (6) in her opening match at the WTA Finals. In a contest between two former No. 1-ranked players, the third-seeded Pliskova struggled early adjusting to the nearly 5,000-feet altitude of Guadalajara, Mexico's second largest city on Wednesday.
The ruthless American needed less than an hour to defeat Sharapova 6-1, 6-1 and notch her 19th consecutive win over the Russian in what some charitably dub a "rivalry."
This will be her first appearance at the tournament since she was ousted in the second round in 2017.
World number six Marin Cilic will be the biggest international star in the singles field at the upcoming Chennai Open, the only ATP 250 tournament in India.
Andy Murray suffered his first defeat in nearly three months on Thursday when he was beaten by Latvia's Ernests Gulbis in the third round of the Rogers Cup. Playing just his second match since winning Wimbledon, Murray fell 6-4, 6-3 in less than an hour and a half in one of the key lead-up events to the US Open.
Sinner is most likely to upset the applecart after the Italian's run to the Canadian Open title this month
French Open champion Barty exited the tournament in the last 16 but regained the number one spot after last year's champion Naomi Osaka was also knocked out at the same stage.
